This comprehensive and multi-year dataset (2013-2023) was collected from open-source information (i.e., government reports, police reports, post-mortem reports, prison records, etc.) alongside published online media reports regarding victimological circumstances, location(s) of body recovery, circumstances surrounding body recovery, method of homicide, geographic considerations, arrest information of suspect(s) if applicable, conviction(s) if applicable, antemortem injuries, post-mortem injuries, and post-mortem actions of suspect(s) was examined to provide a descriptive account of these US transgender and gender non-conforming homicides. The dataset was constructed over the course of several years to identify forensic and investigative themes in homicides involving transgender and gender non-conforming victims.