This is the raw data for the research that validated the performance of Olive-Castor Oil (OL-C) vs. that of octadecylsilane (ODS) in bio-membrane simulation on a planar chromatographic platform by determining the retention characteristics of a number of opiods with similar pharmacophore, using a methanol/water binary mixture of varying compositions as mobile phase on the two platforms. The rationale was that the OL-C model was previously reported as possessing a fairly complex architecture compared to routinely used models like octadecylsilane (ODS).