Data for the research on "Validation of Olive-Castor oil (OL-C) blend as a bio-membrane model"

Adeyemo, Morenikeji A, Rufai, Basirat O, Fatokun, Amos A ORCID: https://orcid.org/0000-0001-5183-7589 and Idowu, Sunday O (2025) Data for the research on "Validation of Olive-Castor oil (OL-C) blend as a bio-membrane model". [Data Collection]

Abstract

This is the raw data for the research that validated the performance of Olive-Castor Oil (OL-C) vs. that of octadecylsilane (ODS) in bio-membrane simulation on a planar chromatographic platform by determining the retention characteristics of a number of opiods with similar pharmacophore, using a methanol/water binary mixture of varying compositions as mobile phase on the two platforms. The rationale was that the OL-C model was previously reported as possessing a fairly complex architecture compared to routinely used models like octadecylsilane (ODS).

Additional Information:	EMBARGO REQUESTED BY DEPOSITING USER: Embargo name: 12 months Depositing user's comment: This is to allow us to get the associated manuscript published before the data is openly accessible. ----- Depositing user's licence comment:
Creators:	Adeyemo, Morenikeji A, Rufai, Basirat O, Fatokun, Amos A ORCID: https://orcid.org/0000-0001-5183-7589 and Idowu, Sunday O
Uncontrolled Keywords:	Lipophilicity; Validation; Octadecylsilane; Olive-Castor Oil; Retention behaviour; Biomimetic; Biomembrane; Permeability; 3401 Analytical chemistry; 321405 Pharmaceutical sciences
DOI:	https://doi.org/10.24377/LJMU.d.00000238
Division:	Pharmacy & Biomolecular Sciences
Field of Research:	Biomedical and clinical sciences > Pharmacology and pharmaceutical sciences > Pharmaceutical sciences Chemical sciences > Analytical chemistry
Date Deposited:	10 Jul 2025 10:22
Last Modified:	10 Jul 2025 10:22
URI:	https://opendata.ljmu.ac.uk/id/eprint/238
Data collection method:	Lipophilicity was evaluated using reversed-phase thin layer chromatographic procedure on silica gel plate. The retention characteristics of some opiods with similar pharmacophore were determined using a methanol/water binary mixture of varying compositions as mobile phase on OL-C and ODS platforms. In vivo biological parameters were computed with the preADMET software. The degree of agreement in lipophilicity measurements by the two biomembrane models (OL-C and ODS) was determined by the Bland-Altman plot.
Resource language:	English
Metadata language:	English
Collection period:	From To 1 July 2018 28 February 2019